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目的 探讨白细胞介素－１（ＩＬ－ｌ）、白细胞介素－２（ＩＬ－２）、白细胞介素－６ （ＩＬ－６）在毒性弥漫性甲状腺肿（ＧＤ）中的致病作用。方法５０例ＧＤ患者在确诊时用放射免疫法测定血清ＩＬ－ｌ、ＩＬ－２、ＩＬ－６、促甲状腺激素（ＴＳＨ）、总甲状腺原氨酸（ＴＴ３）、总甲状腺素（ＴＴ４）的水平。２５例年龄与性别相匹配的健康志愿者作为正常对照。结果①与正常对照组相比，ＧＤ组ＩＬ－２的水平有不同程度的降低，ＩＬ－１、ＩＬ－６的水平均有不同程度的升高。②ＴＴ３、ＴＴ４水平升高，ＩＬ－２水平的下降与ＴＴ３、ＴＴ４水平的升高呈直线负相关；ＴＴ３、ＴＴ４水平升高，ＩＬ－１、ＩＬ－６水平的升高与ＴＴ３、ＴＴ４水平的升高呈直线正相关。结论 ＧＤ 患者血清ＩＬ－１．ＩＬ－２、ＩＬ－６水平的变化可能与ＧＤ的发生发展有一定关系。
Objective To investigate the pathogenic role of interleukin-1, interleukin-2 and interleukin-6 in toxic diffuse goiter (GD). Methods Serum levels of IL-1, IL-2, IL-6, thyroid stimulating hormone (TSH), total thyroxine (TT3) and total thyroxine (TT4) were measured by radioimmunoassay in 50 GD patients at the time of diagnosis. . Twenty-five healthy volunteers aged and sex matched as normal controls. Results ① Compared with the normal control group, the level of IL-2 in GD group decreased to some extent, and the levels of IL-1 and IL-6 increased to some extent. The levels of TT3 and TT4 were increased, and the decrease of IL-2 level was negatively correlated with the levels of TT3 and TT4. The levels of TT3 and TT4 were increased, while the levels of IL-1 and IL-6 were increased with the levels of TT3 and TT4 Elevated positive linear correlation. Conclusion GD patients serum IL-1. IL-2, IL-6 levels may be related to the occurrence and development of GD have a certain relationship.