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目的探讨哌替啶不同给药途径下瘙痒发生率有何差异。方法将盐酸哌替啶1mg/kg(浓度5%)经滴鼻、口服、皮下注射、直肠注药、肌肉注射、静脉注射、硬膜外腔注射、蛛网膜下腔注射(分别为Ⅰ～Ⅷ组,每组50例),然后观察瘙痒发生率。结果各组瘙痒发生为Ⅷ组41例(82%);Ⅶ组31例(62%);Ⅰ、Ⅴ、Ⅵ组各1例(2%);余组0例。Ⅷ及Ⅶ组明显高于其它各组(P<0.01),Ⅷ高于Ⅶ组(P<0.05),Ⅰ～Ⅵ组间无差异。结论派替啶蛛网膜下腔注射时最易发生瘙痒,硬膜外腔注射次之,而哌替啶经滴鼻、口服、皮下注射、直肠注射、肌肉注射、静脉注射时瘙痒发生率低。
Objective To investigate the differences in the incidence of itch between different routes of administration of pethidine. Methods Pethidine hydrochloride 1 mg / kg (concentration 5%) was intranasally, orally, subcutaneously, rectally, intramuscularly, intravenously, epidurally and subarachnoidly Group, 50 cases in each group), and then observe the incidence of itching. Results The incidence of itching in each group was 41 cases (82%) in group Ⅷ, 31 cases (Ⅶ) in group Ⅶ, and 1 case (2%) in group Ⅰ, Ⅴ and Ⅵ. Ⅷ and Ⅶ were significantly higher than other groups (P <0.01), Ⅷ higher than Ⅶ (P <0.05), Ⅰ ~ Ⅵ no difference between groups. Conclusion Epididymal subarachnoid injection of the most prone to itching, epidural injection second, and pethidine by intranasal, oral, subcutaneous injection, rectal injection, intramuscular injection, intravenous injection of low incidence of itching.