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原发住肝癌易发生肝内转移，其术后复发率很高。为寻找有效的方法以降低术后的复发率，我们用抗ｐ５３和抗ＰＣＮＡ单克隆抗体对１０２例手术切除的肝癌标本作免疫组化检测。本文分析了肝癌的不同病理形态，ｐ５３，ＰＣＮＡ情况，结果表明：ＰＣＮＡ指数与ｐ５３的表达呈正相关系，ＰＣＮＡ指数与肿瘤大小，肿瘤包膜，组织分化程度无统计学差异；ｐ５３的表达多见于大肝癌中，但与肿瘤包膜，组织分化程度无统计学差异。ＰＣＮＡ和ｐ５３的免疫组化方法虽然简单，但实用，能为预后和临床治疗提供有用的指标，高指数ＰＣＮＡ或高表达ｐ５３的肝癌术后复发率高，预后差；这些病人术后应接受积极的辅助治疗，术后的介人治疗（栓塞化疗）能降低其术后复发率，提高生存率。
Primary liver cancer is prone to hepatic metastasis, and its postoperative recurrence rate is high. To find effective methods to reduce the recurrence rate after surgery, we performed immunohistochemical detection of 102 surgically resected hepatoma specimens with anti-p53 and anti-PCNA monoclonal antibodies. This article analyzed the different pathological morphology of liver cancer, p53, PCNA, the results showed that: PCNA index and p53 expression was a positive relationship, PCNA index and tumor size, tumor capsule, tissue differentiation was not statistically different; p53 expression more common in Large liver cancer, but with the tumor capsule, no significant difference in the degree of tissue differentiation. The immunohistochemical methods of PCNA and p53 are simple but practical, and can provide useful indicators for prognosis and clinical treatment. High-index PCNA or high-expression of p53 has a high recurrence rate and poor prognosis; these patients should receive active postoperative Adjuvant treatment, postoperative interventional therapy (embolization chemotherapy) can reduce its postoperative recurrence rate and improve survival.