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目的:了解α-硫辛酸对糖尿病足介入治疗的影响。方法:选取2005～2008年在我院住院的糖尿病足拟行溶栓治疗的患者33例,分别给予α-硫辛酸和维生素C注射治疗,观察两组的血清CRP、MMP-9、MDA、ABI等,并进行比较。结果:α-硫辛酸组CRP、MMP-9、MDA明显下降,ABI上升,均优于维生素C组。结论:α-硫辛酸可通过改善氧化应激来改善糖尿病足患者的血供,促进溃疡愈合。其作用明显优于传统抗氧化药物。
Objective: To understand the effect of α-lipoic acid on the interventional treatment of diabetic foot. Thirty-three patients with thrombolytic therapy of diabetic foot hospitalized in our hospital from 2005 to 2008 were selected and treated with α-lipoic acid and vitamin C. The serum levels of CRP, MMP-9, MDA, ABI Etc., and compare. Results: α-lipoic acid group CRP, MMP-9, MDA decreased significantly, ABI increased, were better than vitamin C group. CONCLUSION: Alpha-lipoic acid can improve the blood supply of diabetic foot patients by improving oxidative stress and promote ulcer healing. Its role is significantly better than traditional anti-oxidant drugs.