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目的：研究脑腹中隔区精氨酸加压素（ＡＶＰ）在α－黑素细胞刺激素（αＭＳＨ）解热机制中的作用。方法：建立家兔ＥＴ性发热模型，观察侧脑室注射α－ＭＳＨ对家兔ＥＴ性发热反应及脑腹中隔区ＡＶＰ含量的影响。结果：（１）静脉注射ＥＴ（０３μｇ／ｋｇ）引起家兔明显的发热反应（Ｐ＜０００１），并增加脑腹中隔ＡＶＰ含量（Ｐ＜００５）；（２）静脉注射ＥＴ（０３μｇ／ｋｇ）３０ｍｉｎ后，侧脑室注射α－ＭＳＨ（２００ｎｇ／只），能明显抑制家兔发热反应，同时脑腹中隔区ＡＶＰ含量进一步显著增高（Ｐ＜０００１）；（３）侧脑室注射α－ＭＳＨ（２００ｎｇ／只）并不影响家兔正常体温，但增加脑腹中隔区ＡＶＰ含量（Ｐ＜００５）。结论：α－ＭＳＨ的解热作用可能部分是通过腹中隔ＡＶＰ增多来实现的，αＭＳＨ可能是引起发热时脑腹中隔区ＡＶＰ含量增加的一个重要因素。
Objective: To study the role of arginine vasopressin (AVP) in the heat-clearing mechanism of α-MSH in the ventral septal area of the brain. Methods: The ET fever model in rabbits was established. The effects of intracerebroventricular injection of α-MSH on ET febrile seizures and AVP contents in the ventral septal area of rabbits were observed. Results: (1) Intravenous injection of ET (03 μg / kg) caused a significant fever response in rabbits (P <0001) and increased intracerebellar AVP levels (P0.05); (2) Intravenous injection of α-MSH (200ng / kg) for 30min after injection of ET (03μg / kg) significantly inhibited the fever response in rabbits and the AVP content in the ventral septal area was significantly higher (P0.01) ; (3) Intracerebroventricular injection of α-MSH (200ng / only) did not affect the normal body temperature in rabbits, but increased the content of AVP in the ventral septal area (P <005). Conclusion: The antipyretic effect of α-MSH may be partly realized through the increase of AVP in the ventral septum. Α-MSH may be an important factor in the increase of AVP in the ventral septal area when fever occurs.