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目的介绍一种新的研究（SAP）肠道屏障功能损害的动物模型。方法小型猪无菌手术行中心静脉插管、肠系膜下静脉和门静脉插管、胰管插管、空肠造口和膀胱造瘘。气相色谱法测定尿中乳果糖和甘露醇含量比值反映肠道通透性。高分辨胃肠功能测定仪测量肠道动力。用对氨基马尿酸法测定门静脉血流量反映肠道血供。结果与结论通过和其他研究SAP模型相比较，该模型主要具有如下优点；在清醒状态下连续动态同步观测同一动物在SAP后一段较长时间内（1周或2周）肠道通透性、血供及脑动力等的变化情况，更好地反映这几个因素之间的关系。
Objective To introduce a new animal model of impaired intestinal barrier function in SAP. Methods Mini-pigs underwent aseptic surgery with central venous catheterization, inferior mesenteric vein and portal vein catheterization, pancreatic duct intubation, jejunostomy and cystostomy. Gas chromatographic determination of urine lactulose and mannitol content ratio reflects the intestinal permeability. High-resolution gastrointestinal function meter to measure intestinal motility. Determination of portal vein blood flow with p-amino-hippuric acid method to reflect intestinal blood supply. RESULTS AND CONCLUSIONS Compared with other SAP models, this model mainly has the following advantages: continuous observation of the same animal’s gut permeability for a long time period (1 week or 2 weeks) Changes in blood supply and brain motility, etc., better reflect the relationship between these several factors.