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血糖水平正常的原发性甲状旁腺机能亢进(p-HPT)患者可见高胰岛素血症,而且,胰岛素对各种刺激的反应也增加。为了阐明剂量依赖性的胰岛素对葡萄糖利用的影响,作者用序列正常血糖胰岛素钳夹技术对 PHPT 患者在甲状旁腺腺瘤切除前、后进行了研究。病人和方法有症状的 PHPT 患者6例,女4例,男2例,年龄51.6±9.39岁,体重指数(BMI)22.65±1.64kg/m~2。分别在单个甲状旁腺腺瘤切除前和后8周进行正常血糖胰岛素钳夹试验,即胰岛素输注率0.1,0.2和0.3u/(kg BW·h),每次120min;以输注20%葡萄糖使血糖维持在4.32
Hyperinsulinemia is seen in patients with normal hyperparathyroidism with primary hyperparathyroidism (p-HPT), and insulin response to various stimuli is also increased. In order to elucidate the effect of dose-dependent insulin on glucose utilization, we performed a study of patients with PHPT before and after parathyroid adenoma excision using a series of normoglycemic insulin clamps. There were 6 patients and 4 women with symptomatic PHPT and 2 patients, aged 51.6 ± 9.39 years, with a body mass index (BMI) of 22.65 ± 1.64 kg / m ~ 2. The normal blood glucose insulin clamp test was performed at 8 weeks before and after the resection of single parathyroid adenoma, that is, the insulin infusion rates were 0.1, 0.2 and 0.3 u / (kg BW · h) for 120 min each. Infusion of 20% Glucose keeps blood sugar at 4.32