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用玻璃微电极细胞外记录方法，记录中脑导水管周围灰质（ＰＡＧ）内痛兴奋神经元（ＰＥＮ）的单位放电。主要观察中脑楔状核（ＮＣＦ）尾部给予纳洛酮对ＰＡＧ内ＰＥＮ的痛放电影响。结果：①ＮＣＦ内微量注入纳洛酮（５．５×１０－３ｍｏｌ／Ｌ）能增加ＰＡＧ内ＰＥＮ的痛放电频率。②而预先注射纳洛酮（５．５×１０－３ｍｏｌ／Ｌ）能部分阻断吗啡对ＰＡＧ内ＰＥＮ痛放电抑制效应。提示：ＮＣＦ内某些神经元与脑刺激镇痛有关；内源性吗啡可能是ＮＣＦ抗伤害感受作用中的递质或调质。
Unit discharges of pain excitatory neurons (PEN) within the periaqueductal gray (PAG) were recorded using a glass microelectrode extracellular recording method. To observe the effect of naloxone on the painful discharge of PEN in PAG in the caudal midbrain wedge nucleus (NCF). Results: (1) Naloxone (5.5 × 10-3mol / L) can significantly increase the painful discharge frequency of PEN in PAG. Preinjection of naloxone (5.5 × 10-3mol / L) could partially block the inhibitory effect of morphine on PEN pain discharge in PAG. Tip: Some neurons in NCF are associated with brain stimulation of analgesia; endogenous morphine may be a neurotransmitter or quencher of NCF antinociception.