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背景 有假设认为,男性胎儿比女性胎儿更易受胎母针对D抗原的同种免疫的影响。研究设计与方法 作者对连续收治的104例胎儿为D~+(51例男性,53例女性)及母体抗D效价>16的妊娠情况进行了回顾性分析。结果60例胎儿(58％)接受了子宫内输血。男性胎儿比女性胎儿需要更多输血(5.0对2.0,P=0.0001)。初次输血时,男性胎儿的妊娠龄(24.5周对31.0周,P=0.0007),脐血血红蛋白浓度(6.54对8.75g/dl,P=0.01)及血细胞比容(19.8对26.8％,P=0.004)均较女性胎儿低。
Background It is postulated that male fetuses are more susceptible to alloimmune immunity of the fetus against the D antigen than female fetuses. Study Design and Methods The authors conducted a retrospective review of 104 consecutive fetuses with D ~ + (51 males and 53 females) and maternal anti-D titers> 16 pregnancies. Results 60 fetuses (58%) underwent intrauterine transfusion. Male fetuses require more blood transfusions than female fetuses (5.0 vs. 2.0, P = 0.0001). At the time of initial transfusion, the gestational age of the male fetus (24.5 weeks vs 31.0 weeks, P = 0.0007), cord blood hemoglobin concentration (6.54 vs 8.75 g / dl, P = 0.01) and hematocrit (19.8 vs 26.8% ) Are lower than female fetuses.