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[目的]观察红花注射液联合低分子肝素治疗不稳定型心绞痛疗效。[方法]使用随机平行对照方法,将128例住院患者按病志号抽签方法简单随机分两组。对照组64例低脂饮食,单硝酸异山梨酯40mg,1次/d;阿司匹林100mg,1次/d;辛伐他汀10mg,1次/晚;心绞痛发作时舌下含服消心痛或速效救心。治疗组64例红花注射液20m L+5%葡萄糖250m L,静脉滴注,1次/d;低分子肝素钙5000U皮下注射,2次/d,连用1周后减为1次/d。连续治疗14d为1疗程。观测临床症状、血小板活化因子(CD62p、CD63)、心电图、不良反应。连续治疗2疗程,判定疗效。[结果]治疗组显效28例,有效32例,无效4例,总有效率93.75%。对照组显效23例,有效28例,无效13例,总有效率79.69%。治疗组疗效优于对照组(P<0.05)。CD62p、CD63两组均有明显降低(P<0.05),治疗组降低优于对照组(P<0.01)。[结论]红花注射液联合低分子肝素治疗不稳定型心绞痛,疗效满意,无严重不良反应,值得推广。
[Objective] To observe the curative effect of safflower injection combined with low molecular weight heparin on unstable angina pectoris. [Methods] Using randomized parallel control method, 128 inpatients were randomly divided into two groups randomly according to the method of lot drawing. The control group of 64 cases of low-fat diet, isosorbide mononitrate 40mg, 1 / d; aspirin 100mg, 1 / d; simvastatin 10mg, 1 / night; angina pectoris sublingual convulsion or quick relief . The treatment group, 64 cases of safflower injection of 20m L + 5% glucose 250m L, intravenous infusion, 1 / d; low molecular weight heparin 5000U subcutaneous injection, 2 times / d, once every 1 week and then reduced to 1 / d. Continuous treatment 14d for a course of treatment. Clinical symptoms, platelet activating factor (CD62p, CD63), electrocardiogram, adverse reactions were observed. Continuous treatment of 2 courses to determine the efficacy. [Result] In the treatment group, 28 cases were markedly effective, 32 cases were effective, 4 cases were ineffective, and the total effective rate was 93.75%. The control group was effective in 23 cases, effective in 28 cases, ineffective in 13 cases, the total effective rate was 79.69%. The treatment group was better than the control group (P <0.05). The CD62p and CD63 levels in both groups were significantly lower (P <0.05), and the treatment group was better than the control group (P <0.01). [Conclusion] The combination of safflower injection and low molecular weight heparin in the treatment of unstable angina pectoris has satisfactory curative effect and no serious adverse reactions, which deserves promotion.