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目的从病理学角度探讨翼状胬肉发生发展的机制。方法选择临床切除的复发及原发胬肉材料共50例,分头、体、尾部行苏木素-伊红染色及透射电镜观察。结果进行期胬肉表面复层鳞状上皮化生明显,杯状细胞数量多于静止期。浅层毛细血管较静止期胬肉增多,可见新生毛细血管内皮细胞异常连接,胶原纤维排列形态紊乱,成纤维细胞胞核见分裂相,胶原纤维及弹性纤维大量变性,可见中电子密度均质物及大量空泡变性胶原。空泡变性的成纤维细胞内可见线粒体肿胀,各种细胞器结构不清。结论翼状胬肉有明显的胶原纤维变性,研究提示氧自由基可能参与胬肉组织发生发展进程。
Objective To explore the mechanism of the development of pterygium from the perspective of pathology. Methods A total of 50 cases of recurrent and primary pterygium were selected and stained with hematoxylin-eosin and observed by transmission electron microscopy. Results The squamous cell metaplasia squamous metaplasia was obvious, the number of goblet cells more than the quiescent period. Shallow capillaries more quiescent pterygium increased, showing abnormal connections of newborn capillary endothelial cells, collagen fibers arranged in disorder, fibroblasts see the split phase of the nucleus, a large number of degeneration of collagen fibers and elastic fibers, showing the density of electron density homogeneous material And a large number of vacuolar degeneration of collagen. Degeneration of fibroblasts visible mitochondria swelling, a variety of organelles unclear. Conclusion The pterygium has obvious collagen fibrosis, the research suggests that oxygen free radicals may participate in the occurrence and development of pterygium.