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目的探讨子宫平滑肌瘤的发生与细胞凋亡的关系。方法采用免疫组化技术监测子宫肌瘤患者的肌瘤核组织（实验组）及其周围正常肌组织（对照组）中，ｐ５３基因蛋白产物、Ｆａｓ配体（Ｆａｓ－Ｌ）基因蛋白产物及Ｂｃｌ－２基因蛋白产物的表达。结果实验组各项阳性表达：ｐ５３蛋白为３６６７％，Ｆａｓ－Ｌ蛋白为５６６７％，Ｂｃｌ－２蛋白为７７４２％；对照组各项阳性表达：ｐ５３蛋白为２０００％，Ｆａｓ－Ｌ蛋白为９０００％，Ｂｃｌ－２蛋白为４４８３％。实验组Ｆａｓ－Ｌ蛋白的表达明显低于对照组（Ｐ＜００１），而Ｂｃｌ－２蛋白的表达则明显高于对照组（Ｐ＜００１）。结论子宫肌瘤的发生与细胞凋亡异常有密切关系。
Objective To investigate the relationship between uterine leiomyomas and apoptosis. Methods Immunohistochemistry was used to detect the expression of p53 gene protein, Fas ligand (Fas-L) gene protein and Bcl-2 protein in fibroid tissue (experimental group) and its surrounding normal muscle tissue (control group) -2 gene protein product expression. Results The positive expression of p53 in experimental group was 3667% for p53 protein, 5667% for FasL protein and 7742% for Bcl2 protein. The positive expression of p53 protein in control group was 2000% Fas-L protein was 9000%, Bcl-2 protein was 4483%. The expression of Fas-L protein in the experimental group was significantly lower than that in the control group (P <001), while the expression of Bcl-2 protein was significantly higher than that in the control group (P <001). Conclusion The occurrence of uterine fibroids and apoptosis are closely related.