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肿瘤专家虽然到1984年末还将无法治愈肿瘤,但现在可以大有希望地说,他们将能很好地了解中心的问题,即:细胞的增殖受什么控制?致癌基因是可以被异常激活的正常的细胞基因,其后果是引起细胞的异常增殖。1983年研究的一大飞跃是发现巳知的一种致癌基因为一种众所周知的生长因子,即血小板衍生的生长因子(PDGF)编码。发现上述结果的伦敦帝国肿瘤研究基金会的Mike Waterfield及其同事们现又发现第二种致癌基因,能为促使细胞对生长因子作出反应的受体编码,这种生长因子被称为表皮生长因子(EGF)。几乎与此同时,在美国的一个研究小组也证明,生长因子PDGF可激活另一种致癌基因,可能是直接
Although oncologists will not be able to cure tumors by the end of 1984, it is now possible to say with great promise that they will be able to understand the central issue well: What is the control of the proliferation of cells? Carcinogenic genes can be activated abnormally The consequence of the cellular gene is that it causes abnormal cell proliferation. A major leap forward in the 1983 study was the discovery of a well-known oncogene as a well-known growth factor, the platelet-derived growth factor (PDGF) code. Mike Waterfield and his colleagues at the London Imperial Cancer Research Foundation, who discovered the above results, have now discovered that the second oncogene, which encodes a receptor that responds to growth factors, is called epidermal growth factor. (EGF). Almost at the same time, a research team in the United States has also proved that PDGF can activate another oncogene, which may be direct