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目的比较阿托品治疗有机磷中毒3种给药方式的临床疗效。方法临床观察270例有机磷中毒的患者,随机分成3组,每组90例,第一组患者给予微量泵持续静脉推注,第二组患者给予间隔静脉推注,第三组给予静脉滴注,阿托品给药量均为15mg/h,比较三组患者达到阿托品化的时间及临床治疗效果。结果快速阿托品化平均时间最短的是微量泵持续静脉推注给药方式组,达到阿托品化的时间为(145.3±30.4)分钟,静脉推注给药方式组达到阿托品化的时间为(192.7±45.8)分钟,静脉滴注给药方式组的平均达到阿托品化的时间是最长的,为(213.6±48.7)分钟,三组间比较存在显著性差异(P<0.05);微量泵持续静脉推注的治愈率在三组中是最高的,治愈率为93.33%,静脉推注给药方式的治愈率为88.89%,静脉滴注给药方式的治愈率在三组中是最低的,治愈率为84.44%。结论使用微量泵持续静脉推注可以节省抢救时间,增强临床解毒效果。
Objective To compare the clinical efficacy of atropine in treating three kinds of organophosphate poisoning. Methods The clinical observation of 270 cases of organophosphate poisoning patients were randomly divided into three groups of 90 cases, the first group of patients given continuous intravenous injection of micro-pump, the second group of patients given intravenous injection, the third group given intravenous infusion , Atropine dose were 15mg / h, compared three groups of patients to achieve atropine time and clinical treatment. Results The most rapid atropisolization time was the continuous intravenous bolus injection mode group, the time to achieve atropine was (145.3 ± 30.4) minutes, intravenous bolus administration group to achieve the time of atropine (192.7 ± 45.8 ) Minutes, the mean time to atropine administration was the longest in the intravenous drip group (213.6 ± 48.7) minutes, with significant difference between the three groups (P <0.05); the continuous intravenous bolus injection The cure rate was the highest in three groups, the cure rate was 93.33%, the cure rate of intravenous injection was 88.89%, the cure rate of intravenous drip mode was the lowest among the three groups, the cure rate was 84.44%. Conclusion Continuous intravenous injection of micro-pump can save the rescue time and enhance clinical detoxification effect.