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本文研究了硫酸巯基乙烷钠(Mesna)对N—亚硝基—N—丁基—(4—羟基丁基)胺(BBNOH)诱发大鼠膀胱癌的影响。240只雄性SD大鼠,平均年龄100±5天,常规饲养,随机分成六组。第一、二组(每组45只)为大剂量BBNOH实验组,每公斤体重给药44毫克,BBNOH配成4.4％的混悬液由胃管给药,每周二次。第三、四组(每组45只)为小剂量BBNOH实验组,每公斤体重给药28毫克,配成2.8％混悬液同样方法给药,每周二次。第五、六组(每
In this paper, we investigated the effect of Mesna on rat bladder cancer induced by N-nitroso-N-butyl- (4-hydroxybutyl) amine (BBNOH). 240 male SD rats, mean age 100 ± 5 days, routinely housed, were randomly divided into six groups. The first and second groups (45 rats each) were high-dose BBNOH experimental group, 44 mg / kg body weight and 4.4% suspension of BBNOH were administered by gastric tube twice a week. The third and fourth groups (45 in each group) were small dose BBNOH experimental group, 28 mg / kg body weight, dubbed 2.8% suspension the same way, twice a week. Fifth, six groups (each