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在低ｐＨ静脉注射用人免疫球蛋白（ＩＶＩＧ）的制备中，采用有机溶剂／表面活性剂处理和低ｐＨ放孵（２３°Ｃ～２５°Ｃ，２１天）进行病毒灭活，以提高ＩＶＩＧ的安全性，两法累积灭活效果为：＞８ｌｏｇＨＩＶ－Ⅰ；＞１１．３ＬｏｇＶＳＶ和＞１０．８ＬｏｇＳｉｎｄｂｉｓ。
In the preparation of human immunoglobulin (IVIG) for low pH intravenous injection, virus inactivation was performed with organic solvent / surfactant treatment and low pH incubation (23 ° C ~ 25 ° C, 21 days) Safety, cumulative inactivation effect of the two methods:> 8logHIV-Ⅰ;> 11.3LogVSV and> 10.8LogSindbis.