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目的研究醋氯芬酸(aceclofenac,AC)在多壁碳纳米管修饰玻碳电极(MWCNTs/GCE)上的电化学氧化行为及电化学动力学性质,据此建立AC电化学定量测定方法。方法采用循环伏安法(CV),计时电流法(CA),方波伏安法(SWV)。结果 AC在GCE上于0.59 V处出现一氧化峰,与在GCE上相比,AC在MWCNTs/GCE上峰电位基本不变,峰电流增大约8倍。同时考察了实验条件对AC伏安行为影响,测定了电极反应过程动力学参数,并采用SWV研究了AC氧化峰电流与浓度之间的关系,表明氧化峰电流与其在2.0×10 6～2.0×10 4 mol.L 1内呈良好的线性关系,检出限(S/N=3)1.2×10 7mol.L 1。加样回收率在98.8%～105.0%之间,RSD在1.1%～2.8%之间。结论 AC电催化氧化是一受扩散控制的不可逆电极反应过程,MWCNTs/GCE对AC电化学氧化具有良好的催化作用,据此建立的电化学测定方法可用于市售AC药品含量的电化学定量测定。
OBJECTIVE To study the electrochemical oxidation behavior and electrochemical kinetics of aceclofenac (AC) on MWCNTs / MWCNTs / MWCNTs, and to establish a method for electrochemical quantitative determination of ACcl. Methods Cyclic voltammetry (CV), chronoamperometry (CA) and square wave voltammetry (SWV) were used. Results The AC peak appeared at 0.59 V on GCE. Compared with GCE, the peak potential of AC did not change at MWCNTs / GCE, and the peak current increased about 8 times. The influence of experimental conditions on the AC voltammetry behavior was also investigated. The kinetic parameters of the electrode reaction process were measured. The relationship between the AC peak current and the concentration was studied by SWV. The results showed that the oxidation peak current was in the range of 2.0 × 10 6 ~ 2.0 × 10 4 mol.L 1 showed a good linear relationship, the detection limit (S / N = 3) 1.2 × 10 7mol.L 1. The recoveries of samples ranged from 98.8% to 105.0% with RSD ranging from 1.1% to 2.8%. Conclusion The electrocatalytic oxidation of AC is an irreversible electrode reaction controlled by diffusion. MWCNTs / GCE has a good catalytic effect on electrochemical oxidation of AC. The electrochemical determination method established by this method can be used for the electrochemical quantitative determination of commercial AC drugs .