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自从Hughes和Terenius等人首先报导内源性阿片样肽(endogenous~3opioid peptides EOP)的活性以来,近10年中,EOP的研究进展迅速。目前已知的EOP分为三大类,它们分别是脑啡肽(enkephalin)类,β-内啡肽(β-endorphin)类及新内啡肽(neoendorphin)和强啡肽(dynorphin)类。脑啡肽类主要包括甲硫氨酸脑啡肽(methionine-enkephalin)和亮氨酸脑啡肽(leucine-enkephalin),它们是五肽小分子,来自同一前体-脑啡肽前体(proenkephalin PEN),在组织中的分布较为广泛。β-内啡肽类则由阿片皮质素前体(propio-
Since the first report by Hughes and Terenius et al. On the activity of endogenous 3-opioid peptides EOP, the research on EOP has progressed rapidly in the recent 10 years. The currently known EOPs fall into three broad categories: enkephalin, β-endorphin and neoendorphin and dynorphin. Enkephalins mainly include methionine-enkephalin and leucine-enkephalin, which are small pentapeptides derived from the same proenkephalin (proenkephalin) PEN), the distribution in the organization is more extensive. Beta-endorphins are composed of propio-