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目的探讨肺表面活性物质(固尔苏)联合鼻塞式气道正压通气(NCPAP)对早产儿呼吸窘迫综合征(NRDS)气血指标及并发症的影响。方法 2011年10月至2013年10月确诊的48例NRDS患儿,根据随机数字表将患儿分为观察组及对照组各24例,对照组行机械通气+固尔苏治疗,观察组行NCPAP+固尔苏治疗,比较两组治疗效果。结果观察组患儿机械通气时间、住院时间、家属满意度评分均优于对照组(P均<0.01)。观察组治疗后PaCO2、PaO2、SaO2、pH值高于对照组(P<0.01),且两组并发症发生率具有统计学差异(P<0.05)。结论对NRDS患儿应用固尔苏联合NCPAP治疗效果显著,有利于患儿的预后。
Objective To investigate the effects of pulmonary surfactant (Curetu) combined with nasal obstruction nasal airway pressure (NCPAP) on blood gas index and complications of respiratory distress syndrome (NRDS) in preterm infants. Methods Forty-eight children with NRDS diagnosed from October 2011 to October 2013 were divided into observation group (24 cases) and control group (24 cases) according to random number table. The control group was treated with mechanical ventilation + NCPAP + Cure Su treatment, the treatment effect of two groups were compared. Results The observation group had better mechanical ventilation time, length of hospital stay and satisfaction with family members than the control group (all P <0.01). The PaCO2, PaO2, SaO2 and pH of the observation group were higher than those of the control group (P <0.01), and the complication rates of the two groups were statistically different (P <0.05). Conclusion The treatment of NRDS children with Curel in combination with NCPAP effect is significant, is conducive to the prognosis of children.