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目的：观察槲皮素（Quercetin，Qu）对实验性糖尿病（DM）大鼠心肌损伤的保护作用。方法：用链脲佐菌素（STZ）建造DM大鼠模型。成模后用Qu（50mg．kg-1／d）灌胃处理DM大鼠，6周后测定心肌组织ATP酶活性、总抗氧化能力，并进行超微结构观察。结果：Qu能明显提高DM大鼠心肌Na＋，k＋－ATPase、Ca2＋－ATPase及Mg2＋－ATPase活性，提高心肌及血清总抗氧化能力，降低血清总胆固醇（TC）、谷草转氨酶（SGOP）、肌酸激酶－MB（CK－MB）水平，升高高密度脂蛋白胆固醇（HDL－C），但对血糖及血清甘油三酯无明显影响。经Qu治疗后可显著减轻DM大鼠心肌超微结构及病理改变。结论：Qu对DM大鼠心肌病变具有一定抑制作用，可能与其清除自由基、抑制醛糖还原酶、降低胆固醇等生物活性有关。
Objective: To observe the protective effect of quercetin on myocardial injury in experimental diabetic rats. Methods: DM rat model was established by streptozotocin (STZ). DM rats were treated with Qu (50mg.kg-1 / d) intragastrically after modeling. ATPase activity and total antioxidant capacity of cardiac muscle tissue were measured 6 weeks later, and the ultrastructure was observed. Results: Qu could significantly increase the activity of Na +, k + -ATPase, Ca2 + -ATPase and Mg2 + -ATPase in myocardium of DM rats, increase the total antioxidant capacity of myocardium and serum, decrease the levels of total cholesterol (TC), aspartate aminotransferase MB (CK-MB), elevated HDL-C, but had no significant effect on blood glucose and serum triglycerides. Qu treatment can significantly reduce myocardial ultrastructure and pathological changes in DM rats. Conclusion: Qu can inhibit myocardium of diabetic rats and may be related to the elimination of free radicals, inhibition of aldose reductase and cholesterol lowering.