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目的 优选养肝增免合剂的澄清工艺.方法 以澄清度和阿魏酸含量为指标,在单因素试验基础上,采用正交试验考察壳聚糖加入量、pH、温度等因素对絮凝澄清工艺的影响;考察醇沉浓度、pH、醇沉时间等因素对醇沉工艺的影响.比较2种工艺在最优条件下的澄清效果.结果 壳聚糖絮凝澄清法为最佳工艺,优化工艺为壳聚糖加入量0.1％,体系pH5.0,絮凝时体系温度为45℃.结论 优选的工艺条件稳定、可行,缩短了生产周期,降低了成本,可作为养肝增免合剂的澄清工艺.“,”OBJECTIVE To optimize clarification technology conditions of Yanggan Zengmian mixture.METHODS With the indexes of content of ferulic acid and clarity,based on single factor test,orthogonal design was selected to optimize flocculation technology with chitosan dosage,pH,flocculation temperature as factors.To optimize alcohol precipitation process with alcohol concentration,pH,alcohol deposition time as factors.The clarification effect of the two processes was compared under the opitimized conditions.RESULTS The best clarification technology was chitosan flocculation clarification method,the optimized condition was 0.10％,chitosan flocculating agent was added at pH 5.0 and 45 ℃.CONCLUSION Flocculation clarification method is stable,reliable,short period and lowered production cost,the clarification process can be used for Yanggan Zengmian mixture.