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目的探讨磷酸肌酸钠在治疗心肌炎中的临床疗效。方法将62例心肌炎患儿随机分为2组,治疗组32例,对照组30例,对照组常规给予吸氧、抗病毒、改善心肌代谢及其他对症支持治疗。治疗组在对照组的基础上加用磷酸肌酸钠治疗,两组均治疗10d,比较两组治疗后的症状体征改善、心肌酶谱及心电图的变化。结果治疗组总有效率为87.5%(28/32),对照组为66.6%(20/30),两组总有效率比较差异有统计学意义(χ2=14.83,P<0.01);治疗组的症状体征、心肌酶、肌钙蛋白及心电图的改善均优于对照组(P<0.05)。结论磷酸肌酸钠治疗小儿心肌炎疗效确切,未发现不良反应,值得临床推广。
Objective To investigate the clinical efficacy of sodium creatine phosphate in the treatment of myocarditis. Methods Sixty-two children with myocarditis were randomly divided into two groups. The treatment group was 32 cases and the control group was 30 cases. The control group was routinely given oxygen and antiviral drugs to improve myocardial metabolism and other symptomatic supportive care. The treatment group was treated with sodium creatine phosphate on the basis of the control group. Both groups were treated for 10 days. The improvement of symptoms and signs, changes of myocardial enzymes and electrocardiogram were compared between the two groups. Results The total effective rate was 87.5% (28/32) in the treatment group and 66.6% (20/30) in the control group. There was significant difference between the two groups in total effective rate (χ2 = 14.83, P <0.01) Symptoms and signs, myocardial enzymes, troponin and ECG improved better than the control group (P <0.05). Conclusion Phosphocreatine treatment of pediatric myocarditis exact effect, no adverse reactions, it is worth clinical promotion.