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随着对白血病细胞不断深入研究,临床治疗方法不断改进,近二十年来成人急性白血病的缓解率已上升至60～80％,五年带病生存率亦在提高。目前,急性白血病的患者如能无病生存达7年,可被认为治愈;如果任何部位有过复发,即使血象和骨髓象持续缓解五年以上,最终还是不可能治愈。所以,争取初治后持续完全缓解,是提高治愈率最确切措施。我院内科血液组自1976年以来,积累了三例急性白血病初治持续缓解分别达10年、6.5年和4.5年的长期生存者,其中二例已分别停药5年和1.5年,均无骨髓或髓外复发,现报告于下:
With the continuous research of leukemia cells, clinical treatment methods continue to improve, the rate of remission of adult acute leukemia has risen to 60 ~ 80% in recent two decades, and the five-year survival rate of disease is also increasing. Currently, patients with acute leukemia who survive disease-free for 7 years can be considered cured; if any part of the recurrence, even if the blood and bone marrow continued to relieve more than five years, eventually it is impossible to cure. Therefore, strive for sustained and complete remission after initial treatment, is the most accurate measure to improve the cure rate. Since 1976, three cases of long-term survivors of acute leukemia with initial remission of 10 years, 6.5 years and 4.5 years have been accumulated in our internal medicine blood group. Two of them have been discontinued for 5 years and 1.5 years respectively Marrow or extramedullary recurrence is reported below: