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目的:观察持续血液净化治疗(CRRT)对危重症患者临床疗效及预后的影响。方法:对我院2009年10月—2012年12月收治的合并急性肾功能衰竭需要肾脏替代治疗的22例重症患者进行分析。分为对照组和观察组,每组各11例;对照组给予治疗原发病,纠正休克、补液、抗感染、维持水电解质平衡、加强营养,防治并发症等治疗;观察组在对照组的基础上使用CRRT治疗,比较两组患者血尿素氮、肌酐、血钾、血钠、尿量的变化及患者的临床存活率。结果:观察组治疗前后患者血尿素氮、肌酐、血钾及尿量比较有显著改善(P<0.05),并且较对照组治疗后能明显改善患者的血尿素氮、肌酐、血钾、血钠水平,并且利于肾脏功能的恢复,而且能改善重症患者临床存活率(54.0%vs 36.4%,P<0.01)。结论:CRRT治疗能够维持患者内环境稳定,并且改善重症患者的临床预后。
Objective: To observe the effect of continuous blood purification (CRRT) on the clinical efficacy and prognosis of critically ill patients. Methods: Twenty-two critically ill patients who needed renal replacement therapy in our hospital from October 2009 to December 2012 with acute renal failure were analyzed. Divided into control group and observation group, 11 cases in each group; the control group was given the treatment of primary disease, correct shock, rehydration, anti-infection, maintaining water and electrolyte balance, strengthening nutrition, prevention and treatment of complications; observation group in the control group Based on the use of CRRT treatment, blood urea nitrogen, creatinine, serum potassium, serum sodium, urine volume changes and the clinical survival rate of patients were compared. Results: Before and after treatment, the blood urea nitrogen, creatinine, serum potassium and urine volume in the observation group were significantly improved (P <0.05), and the blood urea nitrogen, creatinine, serum potassium and serum sodium Level, and is conducive to the recovery of renal function, but also improve the clinical survival rate of critically ill patients (54.0% vs 36.4%, P <0.01). Conclusion: CRRT treatment can maintain the stability of patients’ internal environment and improve the clinical prognosis of critically ill patients.