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除对第VII因子直接产生抗体外,对其他凝血因子产生抗体尚属少见。直接对第V因子的抗体更少,有人报告此种抗体既可见于正常止血者,也可见于先天性第V因子缺乏症。作者报告1例79岁男性患者,因Paget病和在股骨骨折后住院内固定、输血。手术后发生精神错乱、心律失常和尿路感染,遂用先锋霉素、奎尼丁和维生素B_(12)。10天后又因血栓性静脉炎而用肝素治疗,9天停用肝素,活化的部分凝血活酶时间明显延长,凝血酶时间亦延长,血小板正常,用维生素K壹周未纠正。因继发于奇异变形杆菌性败血症低血压和急性肾衰,粘膜和穿刺部位少量出血,血小板锐减,纤维蛋白原下降,有少量纤维蛋白(原)降解产物,凝血酶时间延长,红细胞有裂解现象,诊断为弥漫性血管内凝血(DIC)。进一步作凝血
In addition to generating antibodies directly to Factor VII, antibodies to other coagulation factors are rare. There are fewer antibodies directly to factor V, which have been reported to be found in both normal hemostasis and congenital factor V deficiency. The authors report a 79-year-old male with blood transfusions due to Paget’s disease and hospitalization after femoral fracture. Postoperative delirium, arrhythmia and urinary tract infection, then use cephalosporins, quinidine and vitamin B_ (12). 10 days later due to thrombophlebitis with heparin treatment, disable the heparin 9 days, activated thromboplastin time was significantly longer, prolonged thrombin, platelets normal, with vitamin K one week did not correct. Due to secondary to Proteus Bacillus sepsis hypotension and acute renal failure, mucosal and puncture site a small amount of bleeding, platelet decreased sharply, decreased fibrinogen, a small amount of fibrin (proto) degradation products, prolonged thrombin, red blood cell lysis Phenomenon, diagnosed as diffuse intravascular coagulation (DIC). Further coagulation