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目的探讨贝前列素钠联合甲钴胺治疗老年2型糖尿病(T2DM)伴周围神经病变(DPN)的疗效。方法老年T2DM伴DPN患者87例,在常规治疗基础上随机分为两组:A组44例,应用贝前列腺素钠联合甲钴胺治疗;B组43例,单用甲钴胺治疗。两组连续治疗14d。观察临床症状、神经传导速度及不良反应。结果 A组总有效率为84.0%,高于B组的46.5%(P<0.01);A组部分尺神经、胫神经和腓总神经传导速度恢复优于B组(P<0.01)。治疗过程中无明显不良反应。结论贝前列素钠联合甲钴胺治疗老年T2DM伴DPN有效,无明显不良反应。
Objective To investigate the efficacy of beraprost sodium combined with mecobalamin in the treatment of senile type 2 diabetes mellitus (T2DM) with peripheral neuropathy (DPN). Methods A total of 87 elderly patients with T2DM and DPN were randomly divided into two groups according to conventional treatment: 44 cases in group A, benazepril combined with mecobalamin, and 43 cases in group B with mecobalamin alone. Two groups of continuous treatment 14d. Observation of clinical symptoms, nerve conduction velocity and adverse reactions. Results The total effective rate in group A was 84.0%, which was higher than that in group B (46.5%, P <0.01). The conduction velocity of ulnar nerve, tibial nerve and common peroneal nerve in group A was better than that in group B (P <0.01). No obvious adverse reactions in the course of treatment. Conclusion beraprost sodium combined with mecobalamin in the treatment of T2DM elderly patients with DPN effective, no significant adverse reactions.