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目的:评价新辅助动脉化疗在Ⅰb2～Ⅱb期宫颈癌治疗中的临床疗效。方法:对24例Ⅰb2～Ⅱb期宫颈癌患者行新辅助动脉化疗并手术治疗,与21例单纯手术治疗患者在术后病理及疗效等方面进行对比分析。结果:新辅助动脉化疗组总有效率为83.3%(20/24),其中完全缓解7例(29.2%),部分缓解13例(54.2%),症状缓解率87.5%(21/24);化疗反应轻微;术后病理显示:3例(12.5%)标本中未见到癌细胞,15例(62.5%)有宫颈微小癌灶残存,所有切缘均未见癌细胞;术后5年生存率为79.2%,复发率20.8%。而单纯手术组术后病理均可见癌细胞,5年生存率为47.6%,复发率52.4%,2组比较差异有统计学意义(P<0.05)。结论:新辅助动脉化疗治疗Ⅰb2～Ⅱb期宫颈癌疗效明显,不良反应轻,可提高患者的生存质量。
Objective: To evaluate the clinical effect of neoadjuvant artery chemotherapy in the treatment of stage Ⅰb2 ~ Ⅱb cervical cancer. Methods: Twenty-four patients with stage Ⅰb2 ~ Ⅱb cervical cancer underwent neoadjuvant arterial chemotherapy and were surgically treated with 21 cases of simple surgical treatment in postoperative pathology and curative effect comparison. Results: The total effective rate of neoadjuvant arterial chemotherapy group was 83.3% (20/24), of which 7 cases (29.2%) were completely relieved, 13 cases (54.2%) partially relieved, and 87.5% (21/24) The pathological results showed that no cancer cells were observed in 3 cases (12.5%), 15 cases (62.5%) had residual cervical micro-lesions, and no cancer cells were found in all the margin. The 5-year survival rate 79.2%, the recurrence rate was 20.8%. However, the pathological changes in the operation group were all obvious. The 5-year survival rate was 47.6% and the recurrence rate was 52.4%. There was significant difference between the two groups (P <0.05). Conclusion: Neoadjuvant arterial chemotherapy for stage Ⅰb2 ~ Ⅱb cervical cancer has obvious curative effect and mild adverse reactions, which can improve the quality of life of patients.