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目的:探讨宫颈细胞DNA倍体分析在临床上的应用,为宫颈病变的临床诊断提供理论依据。方法:选取2012年4月至2014年4月在我院进行宫颈分泌物检查的1660例患者作为研究对象,分别对患者采用常规液基检查及DNA倍体分析,对于检验阳性者再采进行阴道镜下活检,对比两种检测方法的临床效果。结果:常规液基检查的阳性率为3.9%;DNA倍体分析检查的阳性率为9.7%,DNA倍体分析检查的阳性率显著高于常规液基检查(P<0.05)。常规液基检查阳性患者经阴道镜下活检的阳性率为67.2%;DNA倍体分析检查阳性患者经阴道镜下活检的阳性率为88.9%,DNA倍体分析检查阳性患者经阴道镜下活检的阳性率显著高于常规液基检查(P<0.05)。结论:宫颈细胞DNA倍体分析在宫颈病变的临床诊断中具有良好应用效果。
Objective: To investigate the clinical application of cervical cell DNA ploidy analysis and to provide a theoretical basis for the clinical diagnosis of cervical lesions. Methods: A total of 1660 patients with cervical secretions examined in our hospital from April 2012 to April 2014 were selected as the study subjects. The patients were examined by routine liquid-based examination and DNA ploidy analysis respectively. Microscope biopsy, comparing the clinical efficacy of the two detection methods. Results: The positive rate of routine liquid test was 3.9%. The positive rate of DNA ploidy test was 9.7%. The positive rate of DNA ploidy test was significantly higher than that of routine liquid test (P <0.05). The positive rate of colposcopic biopsy in routine liquid-based test was 67.2%. The positive rate of colposcopic biopsy by DNA ploidy assay was 88.9%. The positive rate of DNA ploidy assay was negative in colposcopic biopsy The positive rate was significantly higher than the conventional liquid-based examination (P <0.05). Conclusion: DNA ploidy analysis of cervical cells has a good effect in the clinical diagnosis of cervical lesions.