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Krüppel样因子7(Krüppel-like factor 7,KLF7)是Sp1样或Krüppel样转录因子家族(specificity protein/Krüppel-like factor,SP/KLF)成员,在多种生物学过程中发挥重要作用,该基因完全敲除小鼠出生时大部分死亡.KLF7是肥胖症、Ⅱ型糖尿病、心血管疾病、癌症、面部发育异常、氧化磷酸化缺陷和Ⅰ型自身免疫性胰腺炎等疾病的相关基因.功能分析显示,KLF7是神经系统发育和脂肪形成的关键因子,同时也在肌肉再生和造血作用中发挥功能.在SP/KLF家族中,KLF7研究相对较少,大部分作用机制尚不清楚.本文从结构和功能方面详述了KLF7的最新研究进展,为其和KLFs家族深入研究提供重要的科学依据.
Krüppel-like factor 7 (KLF7) is a Sp1-like or a member of the Krüppel-like family of transcription factors (SP / KLF) that plays an important role in a variety of biological processes. This gene Complete knockout of most of the mice who died at birth was associated with diseases such as obesity, type II diabetes, cardiovascular disease, cancer, facial dysplasia, oxidative phosphorylation defects and type I autoimmune pancreatitis. Showed that KLF7 is a key factor in the development of the nervous system and adipogenesis and also plays a role in muscle regeneration and hematopoiesis.In the SP / KLF family, KLF7 is relatively less studied and most of the mechanism of action is still unclear.In this paper, It also provides a detailed description of the latest research progress of KLF7 and provides an important scientific basis for its further study with the KLFs family.