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孕期慢性高血压的母子死亡率增加,且围产期的危险与高血压的严重程度有关,若伴发预痫则围产期死亡率会更高。很多研究表明孕期高血压行抗高血压治疗是有益的,们对妊娠期轻度慢性高血压患者的治疗价值仍有争论。本文对25例孕期慢性高血压患者行双盲研究,随机分为甲基多巴治疗组(13人)和安慰剂组(12人)。就母亲的平均动脉压(MAP),伴发预痫的频率、妊娠持续时间、胎儿生长和分娩状态以及母子的药物副作用等方而进行了探讨。所有研究对象符合以下标准:(1)两次在不同场合且至少间断6小时的血压为140/90mmHg。(2)无蛋白尿(24小时尿蛋白<100mg)。(3)推断有慢性高血压。(4)孕龄<34周。(5)单
Maternal mortality during pregnancy increases with chronic hypertension, and perinatal risk and the severity of hypertension, if accompanied by pre-eclampsia perinatal mortality will be higher. Many studies have shown that antihypertensive treatment of hypertension during pregnancy is beneficial, they are still controversial treatment of mild chronic hypertension in pregnancy. In this study, 25 pregnant women with chronic hypertension were randomly divided into two groups: metoprolol group (13 persons) and placebo group (12 persons). The mean arterial pressure (MAP), the frequency of preeclampsia, the duration of pregnancy, the status of fetal growth and childbirth, and the side effects of mother and child were also discussed. All subjects met the following criteria: (1) Blood pressure was 140/90 mmHg twice at different occasions with at least 6 hours of discontinuation. (2) proteinuria (24 hours urinary protein <100mg). (3) Inferred with chronic hypertension. (4) gestational age <34 weeks. (5) single