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目的：检测成釉细胞瘤中的ＢＭＰ的表达，探讨成釉细胞瘤的发生及病理机理。方法：采用免疫组化和原位杂交的方法，检测２４例成釉细胞瘤标本中ＢＭＰ蛋白和ＢＭＰ－２、－４ｍＲＮＡ表达。结果：成釉细胞瘤中的柱状上皮层和星网状细胞层中均有ＢＭＰ－２、－４ｍＲＮＡ和ＢＭＰ蛋白的表达，ＢＭＰ－２、－４ｍＲＮＡ的杂交信号强度在柱状上皮层小于星网状细胞。结论：ＢＭＰ的表达为探讨成釉细胞瘤的来源提供了分子基础；ＢＭＰ可能参与了肿瘤病理机理及生物学行为的形成。
Objective: To detect the expression of BMP in ameloblastoma and to investigate the pathogenesis of ameloblastoma. Methods: Immunohistochemistry and in situ hybridization were used to detect the expression of BMP-2, BMP-2 and -4 in 24 specimens of ameloblastoma. Results: The expressions of BMP-2, -4 mRNA and BMP protein in the columnar epithelium and the reticular cell layer of ameloblastoma, respectively. The intensity of the hybridization signal of BMP-2 and -4 mRNA in the columnar epithelium was less than that of the star-reticular cell. CONCLUSION: BMP expression provides the molecular basis for exploring the origin of ameloblastoma. BMP may be involved in the formation of tumor pathology and biological behavior.