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目的：探索中药复方化痰愈心汤及功能药组的钙拮抗作用。方法：用４５Ｃａ跨膜技术测量大鼠主动脉３种钙通道的Ｃａ２＋内流影响。结果：当复方浓度为０．５～５ｍｇ／ｍｌ时，能阻滞大鼠主动脉ＲＯＣ和ＰＤＣ的Ｃａ２＋内流；功能药组的钙拮抗作用以活血组和行气组较好。结论：化痰愈心汤治疗冠心病的机理可能与阻滞细胞膜外Ｃａ２＋内流有关，其作用规律与Ｖｅｒａｐａｍｉｌ相似。
Objective: To explore the calcium antagonism of traditional Chinese medicine compound Huayuxin Decoction and functional drug group. Methods: The effects of Ca2+ influx on the three calcium channels in rat aorta were measured by 45Ca transmembrane technique. Results: When the compound concentration was 0.5 to 5 mg/ml, Ca2+ influx of ROC and PDC in rat aorta could be blocked. The calcium antagonistic effect of functional drug group was better in the Huoxue group and the Xingqi group. Conclusion: The mechanism of Huayu Yuxin Decoction in the treatment of coronary heart disease may be related to the block of extracellular Ca2+ influx, and its action pattern is similar to that of Verapamil.