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目的研究γ-干扰素联合小剂量红霉素治疗小儿支气管哮喘临床效果。方法选取2014年12月—2016年5月于平舆县人民医院接受诊治的72例小儿支气管哮喘患儿,采用随机数字表法分为观察组(n=36)和对照组(n=36),对照组采用常规西医吸入治疗,观察组在对照组基础上加用γ-干扰素与小剂量红霉素治疗,比较两组总有效率、不良反应发生情况。结果观察组总有效率为94.44%,高于对照组总有效率72.22%,差异具有统计学意义(χ~2=13.091,P<0.05);观察组不良反应发生率为2.78%(1/36),低于对照组不良反应发生率22.22%(8/36)。差异具有统计学意义(χ~2=4.571,P<0.05)。结论小儿支气管哮喘采用γ-干扰素与小剂量红霉素治疗,可显著提高治疗效果,安全可靠,值得推广应用。
Objective To study the clinical effects of γ-interferon combined with low-dose erythromycin in treating pediatric bronchial asthma. Methods 72 children with bronchial asthma admitted to Pingyu County People’s Hospital from December 2014 to May 2016 were randomly divided into observation group (n = 36) and control group (n = 36) . The control group was treated with conventional Western medicine inhalation. The observation group was treated with γ-interferon and low-dose erythromycin on the basis of the control group. The total effective rate and adverse reactions of the two groups were compared. Results The total effective rate in the observation group was 94.44%, higher than that in the control group (72.22%), the difference was statistically significant (χ ~ 2 = 13.091, P <0.05). The adverse reaction rate in the observation group was 2.78% ), Which was lower than that of the control group (22.22%, 8/36). The difference was statistically significant (χ ~ 2 = 4.571, P <0.05). Conclusion Bronchial asthma with γ-interferon and low-dose erythromycin treatment can significantly improve the treatment effect, safe and reliable, it is worth promoting the application.