论文部分内容阅读
目的探究通心络胶囊联合美托洛尔缓释片治疗老年冠心病患者的疗效及对其血管内皮功能的影响。方法抽取2014年10月—2016年7月濮阳市油田总医院收治的72例冠心病患者,通过随机数字表法分组,各36例。对照组采用美托洛尔缓释片,研究组采用美托洛尔缓释片+通心络胶囊,两组均持续治疗2个月。统计两组临床疗效,对比治疗前后血管内皮功能[内皮素(ET-1)、一氧化氮(NO)、肱动脉血流介导内皮依赖性血管舒张功能(FMD)]及心功能[心输出量(CO)、左室射血分数(LVEF)、舒张早期峰值速度与舒张末期峰值速度比值(E/A)]水平变化。结果研究组有效率(91.67%)高于对照组(72.22%),差异有统计学意义(P<0.05);治疗前两组NO、ET-1、FMD水平对比无明显差异(P>0.05),治疗后研究组NO、FMD水平高于对照组,ET-1水平低于对照组,差异有统计学意义(P<0.05);治疗前两组CO、LVEF及E/A水平对比无明显差异(P>0.05),治疗后研究组各指标水平高于对照组,差异有统计学意义(P<0.05)。结论联合采用通心络胶囊及美托洛尔缓释片治疗老年冠心病患者效果显著,可改善其心功能及血管内皮功能,提高治疗效果。
Objective To investigate the effect of Tongxinluo capsule combined with metoprolol sustained-release tablets in the treatment of elderly patients with coronary heart disease and its effect on vascular endothelial function. Methods Seventy-two patients with coronary heart disease admitted from Puyang Oilfield General Hospital from October 2014 to July 2016 were selected and randomly divided into three groups according to the random number table (36 cases). Metoprolol sustained-release tablets were used in the control group, metoprolol sustained-release tablets and Tongxinluo Capsule in the study group, and both groups were treated for 2 months. The clinical efficacy was compared between the two groups before and after treatment. Endothelin (ET-1, NO, bradycardia-mediated endothelium-dependent vasodilatation (FMD) (CO), left ventricular ejection fraction (LVEF), peak early diastolic velocity and end diastolic peak velocity (E / A)]. Results The effective rate (91.67%) in the study group was higher than that in the control group (72.22%), the difference was statistically significant (P <0.05); There was no significant difference in the levels of NO, ET- , The levels of NO and FMD in the study group were higher than those in the control group, the ET-1 level was lower than that in the control group (P <0.05), and there was no significant difference in CO, LVEF and E / A levels between the two groups before treatment (P> 0.05). After treatment, the levels of each index in the study group were higher than those in the control group, with significant difference (P <0.05). Conclusion The combination of Tongxinluo capsule and metoprolol sustained-release tablets in the treatment of elderly patients with coronary heart disease significantly improved the cardiac function and vascular endothelial function and improve the therapeutic effect.