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目的:探讨肝素标记超顺磁氧化铁粒子(HepSPIO) 对大鼠肝癌灶的增强作用。材料和方法:应用Gouys 法测定磁化率;应用二乙基亚硝胺建立大鼠化学诱导性肝癌模型;观察静注Hepspio 前后大鼠肝癌的显示情况,并与病理检查对照分析。结果:HepSPIO 的磁化率为201-5 ×10 - 3/g(25 ℃) ;4 只大鼠肝癌模型共有27 个瘤结,平均直径2-4 ±1-3m m 。增强后质子加权像癌灶检出率由平扫的33-3 % (9/27) 提高到74-1 % (20/27) ,病灶对比度/ 噪声比(CNR) 由0-7±1-9 提高至4-2 ±4-0 ;T2 加权像癌灶检出率由平扫的59-3 % (18/27) 提高到77-8 % (22/27) ,CNR 由2-8 ±2-1 上升至3-9 ±3-3 。结论:HEPSPIO 是一种新型磁共振肝网状内皮系统显影剂,对提高肝脏微小病灶的检出率有重要帮助。
Objective: To investigate the enhancement effect of heparin-labeled superparamagnetic iron oxide (HepSPIO) on rat hepatocellular carcinoma. Materials and Methods: The magnetic susceptibility was measured by Goyys method. The rat model of chemically induced hepatocellular carcinoma was established with diethylnitrosamine. The appearance of hepatocellular carcinoma in rats before and after Hepspio injection was observed and compared with pathological examination. RESULTS: The magnetic susceptibility of HepSPIO was 201-5 × 10 -3 /g (25 °C). There were 27 tumor nodes in the 4 rat liver cancer models with an average diameter of 2-4 ±1-3 mm. The detection rate of enhanced proton-weighted imaging lesions increased from 33-3% (9/27) of plain scans to 74-1 % (20/27), and the contrast/noise ratio (CNR) of lesions ranged from 0-7±1. 9 increased to 4-2 ±4-0; the detection rate of T2-weighted imaging lesions increased from 59-3% (18/27) of plain scan to 77-8% (22/27) and CNR from 2-8 ± 2-1 rises to 3-9 ±3-3. Conclusion:HEPSPIO is a new type of MR hepatic reticuloendothelial system imaging agent, which is helpful to improve the detection rate of micro-lesions in the liver.