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目的:分析阿托伐他汀与盐酸小檗碱片联用对糖尿病伴脑梗死患者神经功能的影响及其临床疗效。方法:选取2014年2月—2015年7月间收治的糖尿病伴脑梗死患者92例,按随机分组原则将其分为对照组46例和联合组46例;对照组患者给予阿托伐他汀治疗,联合组患者在对照组基础上加用盐酸小檗碱片治疗;治疗后按神经功能缺损检查量表(NIHSS)对两组患者的神经功能恢复功能进行评分,以及治疗后的总有效率和血糖各指标的测得值。结果:治疗后联合组患者的NIHSS评分值为(8.86±2.13)分低于对照组为(13.44±3.09)分(t=13.46,P<0.05);TG和TC测得值分别为(1.49±0.76)mmol/L和(5.16±1.08)mmol/L低于对照组为(2.07±1.19)mmol/L和(6.21±1.57)mmol/L(t=12.47,13.56,P<0.05);HDL-C测得值高于对照组(t=11.44,P<0.05);联合组患者空腹血糖、餐后2 h血糖以及糖化血红蛋白测得值分别为(6.78±1.32)mmol/L、(8.64±2.16)mmol/L和(6.79±0.48)%均低于对照组(t=13.97,12.46,14.57,P<0.05)。结论:阿托伐他汀与盐酸小檗碱片联用于治疗糖尿病并脑梗死患者的效果更确切,优于单用阿托伐他汀,能显著降低血脂、血糖水平,更利于神经功能的改善和病情的康复。
OBJECTIVE: To analyze the effect of atorvastatin and berberine hydrochloride on neurological function in diabetic patients with cerebral infarction and its clinical efficacy. Methods: Ninety-two patients with diabetes mellitus and cerebral infarction who were admitted between February 2014 and July 2015 were divided into control group (n = 46) and combination group (n = 46) according to the randomization principle. Patients in the control group were given atorvastatin , And the combination group was treated with berberine hydrochloride on the basis of the control group. After treatment, the neurological functional recovery scores of the two groups were scored according to the Neurological Deficiency Examination Scale (NIHSS), and the total effective rate Blood glucose indicators measured values. Results: The NIHSS score of the combined group was (8.86 ± 2.13) points lower than that of the control group (13.44 ± 3.09) (t = 13.46, P <0.05), and the values of TG and TC were (1.49 ± (2.07 ± 1.19) mmol / L and (6.21 ± 1.57) mmol / L (t = 12.47,13.56, P <0.05) C was higher than that of the control group (t = 11.44, P <0.05). The fasting blood glucose, postprandial 2-hour postprandial blood glucose and glycosylated hemoglobin in the combined group were 6.78 ± 1.32 mmol / L, 8.64 ± 2.16 ) mmol / L and (6.79 ± 0.48)% were lower than those in the control group (t = 13.97,12.46,14.57, P <0.05). Conclusions: Combination of atorvastatin and berberine hydrochloride in patients with diabetes mellitus and cerebral infarction is more effective than atorvastatin alone, and can significantly reduce blood lipids and blood glucose levels and improve the neurological function. Rehabilitation of the disease.