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目的:评价氨溴索(商品名沐舒坦)静滴与雾化吸入联用对新生儿肺炎的疗效。方法:将收治的新生儿肺炎患儿88例,分为治疗组(采用静脉滴注加雾化吸入沐舒坦)和对照组(采用静脉滴注沐舒坦),每组44例;两组患者在常规治疗的基础上,治疗组予大剂量沐舒坦,应用微量泵输注与雾化吸入;对照组患者给予微量泵输注沐舒坦治疗,观察两组患儿治疗前后临床表现、并发症的发生率和X-线胸片的变化,以及主要症状消失时间和住院时间的长短。结果:治疗组患者总有效率为95.45%,对照组患者为72.73%,总有效率经比较,其差异有统计学意义(P<0.05);治疗组患者咳嗽消失时间(5.05±1.30)d,气促消失时间(3.12±1.02)d,肺部罗音消失时间(4.02±1.40)d及其住院时间(6.02±1.86)d;对照组患者分别为(6.46±1.38)d,(4.65±1.42)d,(7.66±2.40)d,(9.05±2.40)d,经两两比较其差异有统计学意义(P<0.05)。结论:该法治疗新生儿肺炎,疗效确切,适用于新生儿肺炎的治疗。
OBJECTIVE: To evaluate the efficacy of ambroxol (trade name Mucosolvan) in combination with nebulized inhalation on neonatal pneumonia. Methods: 88 cases of neonates with pneumonia admitted were divided into treatment group (intravenous drip plus inhalation of mucosolvan) and control group (intravenous infusion of mucosolvan), 44 cases in each group; On the basis of routine treatment, the treatment group to high-dose ambroxol, application of micro-pump infusion and inhalation; control group were given micro pump infusion of mucosolvan treatment, the two groups of children before and after treatment to observe the clinical manifestations, complications Rate and X-ray chest changes, as well as the disappearance of the main symptoms and length of hospital stay. Results: The total effective rate was 95.45% in the treatment group and 72.73% in the control group. The total effective rate was statistically significant (P <0.05), and the disappearance time of the cough in the treatment group was 5.05 ± 1.30 days, (3.12 ± 1.02) d, disappearance time of pulmonary rales (4.02 ± 1.40) d and hospital stay (6.02 ± 1.86) d respectively in the control group and (6.46 ± 1.38) d and (4.65 ± 1.42) days in the control group ) d, (7.66 ± 2.40) d, (9.05 ± 2.40) d, respectively. The differences between the two groups were statistically significant (P <0.05). Conclusion: The method of treatment of neonatal pneumonia, curative effect is exact, suitable for the treatment of neonatal pneumonia.