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肝脏在正常的凝血、抗凝和纤溶过程中起重要作用。生理情况下,肝脏合成大多数的凝血因子、抗凝和纤溶因子,同时它还具有清除或灭活被激活因子的作用。当肝脏发生病变时,肝细胞变性和坏死,合成蛋白质和凝血因子的功能降低,特别是维生素K依赖性凝血因子合成减少,会导致凝血、抗凝和纤溶系统的失衡,表现为多种凝血指标的异常[1],临床上表现为出血。
The liver plays an important role in normal coagulation, anticoagulation and fibrinolysis. Physiologically, the liver synthesizes most of the clotting, anticoagulant and fibrinolytic factors, and it also has the effect of clearing or inactivating the activated factor. Degeneration and necrosis of liver cells, decreased function of synthetic proteins and clotting factors, especially reduced synthesis of vitamin K-dependent clotting factors, lead to an imbalance in the coagulation, anticoagulation and fibrinolysis systems, manifested as a variety of coagulation Abnormal indicators [1], clinically manifested as bleeding.