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目的 :通过大样本多中心、随机、双盲、安慰剂对照的临床研究 ,观察金尔伦 (盐酸纳洛酮 )对急性脑梗死的临床疗效。方法 :观察 8家医院 15 0例急性脑梗死患者。随机分为对照组、金尔伦治疗 1组和金尔伦治疗 2组。各组均可给予钙拮抗剂、活血化瘀药、扩容药等常规治疗。对照组使用生理盐水 ,金尔伦治疗 1组每日加 3 .2mg金尔伦 ,静脉滴注 ,治疗 2组每日加 8mg金尔伦 ,静脉滴注 ,三组均连续应用 10d。各组用药前后均进行神经功能缺损评分 ,治疗 3 0d和 90d进行Barthel指数评分并观察副作用。结果 :对于神经功能缺损的改善 ,金尔伦治疗组均优于对照组 ,尤以金尔伦 2组为明显 (P <0 .0 0 5 ) ,而且无明显副作用。结论 :金尔伦有助于阻止急性脑梗死继发性神经元损伤 ,改善临床症状 ,而且安全性较高。
OBJECTIVE: To observe the clinical efficacy of Huron (naloxone hydrochloride) in patients with acute cerebral infarction in a large multicenter, randomized, double-blind, placebo-controlled clinical study. Methods: Fifty patients with acute cerebral infarction in 8 hospitals were observed. Randomly divided into control group, the treatment group 1 and the treatment of two groups. Each group can be given calcium antagonist, blood circulation drugs, dilatation medicine and other conventional treatment. In the control group, normal saline was used in the treatment group, while in the treatment group 1, 3.2 mg of Huron was added daily. The patients in the two groups were treated with 8 mg of erlenium daily and intravenously for 10 days. Neurological deficit scores were obtained before and after treatment in each group. Barthel index was scored on the 30th and 90th days after treatment, and the side effects were observed. Results: For the improvement of neurological deficit, the treatment group of the treatment group was superior to the control group, especially the group of the gall bladder was significantly (P <0.05), and no obvious side effects. Conclusion: Huron helps to prevent secondary neuronal injury in acute cerebral infarction and improve clinical symptoms, and is safe.