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观察尼群地子(Nit)对实验性糖尿病大鼠心肌舒缩功能、心肌琥珀酸脱氢酶和细胞色素氧化酶活性的影响。结果表明,糖尿病发生4周时大鼠心室舒张功能发生改变,8周时心室舒张和收缩功能均明显受累。Nit处理可改善糖尿病大鼠心肌舒缩功能。糖尿病大鼠心肌琥珀酸脱氢酶和细胞色素氧化酶活性比对照组明显下降,接受Nit处理后可明显恢复以上酶的活性。提示Nit处理对大鼠糖尿病性心肌病有一定有益作用。
To observe the effects of nitrendipine (Nit) on cardiac contractile and diastolic function, myocardial succinate dehydrogenase and cytochrome oxidase activity in experimental diabetic rats. The results showed that the left ventricular diastolic function changed after 4 weeks in diabetic rats, and the diastolic and systolic functions were significantly impaired after 8 weeks. Nit treatment can improve myocardial contractile and diastolic function in diabetic rats. The activity of succinate dehydrogenase and cytochrome oxidase in myocardium of diabetic rats decreased significantly compared with the control group, and the activities of the above enzymes were recovered obviously after Nitric acid treatment. Tip Nit treatment of diabetic cardiomyopathy has some beneficial effects.