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目的:探讨隐睾并发精原细胞瘤的临床病理特征。方法:对2例手术切除的小肠精原细胞瘤进行临床、组织学及免疫组织化学观察。结果:肿瘤由大小基本一致的瘤细胞构成,被纤维间隔分隔成巢状或不规则条索状;细胞圆形或多角形,边界清楚;胞质较丰富,多数透亮,部分呈嗜酸性;核圆或椭圆,大而深染,基本位于中央,核分裂多见;可见灶状、片状或大片坏死;间质内纤维组织增生,可见淋巴细胞弥漫性或灶状浸润,部分肿瘤边缘可见残存附睾管。免疫组织化学示PLAP,CD117,HCG和Vim以及CD45RO均阳性,CK,EMA,CD20,AFP,Syn,C gA,HM B45及S-100均阴性。结论:精原细胞瘤的病理诊断应紧密结合临床资料进行。
Objective: To investigate the clinical and pathological features of cryptorchidism complicated with seminoma. Methods: The clinical, histological and immunohistochemical observations of 2 cases of small intestine seminoma were performed. Results: The tumors consisted of tumor cells of basically the same size and were separated into nests or irregular cords by fibrous septa. The cells were round or polygonal with clear boundary. The cytoplasm was rich, translucent and partially eosinophilic. Round or oval, large and deep dyed, basically located in the center, nuclear fission more common; visible focal, flaky or large necrosis; interstitial fibrous tissue hyperplasia, diffuse or focal lymphocyte infiltration can be seen, some of the tumor margin visible residual epididymitis tube. Immunohistochemistry showed positive for PLAP, CD117, HCG and Vim and CD45RO, and negative for CK, EMA, CD20, AFP, Syn, CgA, HM B45 and S-100. Conclusion: The pathological diagnosis of seminoma should be closely combined with clinical data.