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人类遗传性聋及严重的听力损害疾病中,常染色体隐性遗传是最常见的原因。虽因人类易受诸多环境因素的影响而难以判定,但某些进行性听力损害的病因中遗传基因仍具有重要意义。已知鼠类具有大量影响内耳的突变基因,与人类迷路畸变相似的有3种,即形态学突变基因、神经上皮突变基因和耳蜗球囊突变基因。而Jerker鼠属于神经上皮类,在其染色体4上有一个常染色体隐性突变。该文分析了纯合子和杂合子Jerker鼠螺旋器与年龄相关的连
Autosomal recessive inheritance is the most common cause of hereditary deafness and severe hearing impairment in humans. Although it is difficult to judge because of human susceptibility to many environmental factors, the inherited genes in some causes of progressive hearing impairment are still of great significance. Known murine has a large number of mutations affecting the inner ear gene, and human labyrinthine distortion similar to the three kinds of morphological mutations, neuroepithelial mutation gene and cochlear balloon mutation gene. The Jerker rat belongs to the neuroepithelial class and has an autosomal recessive mutation on its chromosome 4. This article analyzes the age-related association of homozygous and heterozygous Jerker rat helix