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曾有人提出,肝硬化时的自发性细菌性腹膜炎,可能系由于短暂的菌血症使有腹水的这一易受侵袭的部位产生感染。亚急性细菌性心内膜炎的发病原理大体上和它相同,但其易受侵袭的部位是瓣页。由于肝硬化患者比非肝硬化患者有更多机会的菌血症,故可想像前者发生亚急性细菌性心内膜炎会多于后者。尸检研究:作者复习了在1954年1月～1974年6月间全部所作的4,215例尸检记录资料,肝硬化和亚急性细菌性心内膜炎均系确诊的。其中肝硬化有542例(12.6％),而亚急性细菌性心内膜炎则有40例(0.95％)。542例肝硬化患者中10例有亚急性细菌性心内膜炎(1.8％),而3,673例非肝硬化患者中则只有30例(0.8％)。二者在统计学上有非常显著差异(P<0.025)。临床研究:在这个时期估计有41,000例患者入院,其中52例有亚急性细菌性心内膜炎(0.13％)。
It has been suggested that spontaneous bacterial peritonitis in cirrhosis may be due to transient bacteremia in asymptomatic parts of the site of infection. The pathogenesis of subacute bacterial endocarditis is largely the same, but its vulnerable site is the flap. Since cirrhotic patients have more chances of bacteremia than non-cirrhotic patients, it is conceivable that the former will have more subacute bacterial endocarditis than the latter. Autopsy Study: The authors reviewed all 4,215 autopsy records from January 1954 to June 1974, with cirrhosis and subacute bacterial endocarditis diagnosed. Of these, 542 (12.6%) had cirrhosis and 40 (0.95%) had subacute bacterial endocarditis. Ten of the 542 cirrhotic patients had subacute bacterial endocarditis (1.8%), compared with 30 (0.8%) of 3,673 non-cirrhotic patients. There was a statistically significant difference between the two groups (P <0.025). Clinical Study: An estimated 41,000 patients were admitted during this period, of which 52 had subacute bacterial endocarditis (0.13%).