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血清γ-谷氨酰转肽酶(Serum γ-Giutamyl-Transpeptidase 以下简称γ-GTP)是近十余年来国内外新开展起来的一项酶学试验。广泛存在于人体肾、肝、胰、脾、肠、脑、骨骼及心肌等组织中,从血清、胆汁、胸水、腹水和尿液中均可测得此酶的活性。它是催化γ-L-谷氨酰基移换反应的一种特殊的转换酶。对于肌体内蛋白质的分解、吸收和合成起着重要的作用。正常血清中γ-GTP 主要来自肝脏,局限于毛细胆管和肝细胞的微粒体中,当肝和胰脏细胞受损甚至发生坏死或恶变时,酶即释放到血液内,或由于胆道受阻,酶逆流到血液中。忠肝癌、胆道癌与阻塞性黄疸等疾病时其活力均可显著增高,其增高率对于筛选有无肝胆疾患是一项可取的指标。为观察此酶在各期血吸虫病临床上的应用价值,1980年我们检测了178例各期血吸虫病患者的γ-GTP,同时作了 SGPT、AKP 的测定。现将结果报告如下:
Serum γ-glutamyl transpeptidase (hereinafter referred to as γ-GTP) is a newly developed enzymatic experiment at home and abroad for more than ten years. It is widely found in human kidney, liver, pancreas, spleen, intestine, brain, bone and myocardium. The activity of this enzyme can be measured in serum, bile, pleural effusion, ascites and urine. It is a special converting enzyme that catalyzes the γ-L-glutamyl shift reaction. For the body of protein decomposition, absorption and synthesis play an important role. Gamma-GTP in normal serum is mainly from the liver, confined to microsomal biliary tract and liver cells, when the liver and pancreatic cells are damaged or even necrosis or malignant transformation, the enzyme is released into the blood, or due to biliary obstruction, the enzyme Countercurrent to the bloodstream. Loyalty to liver cancer, biliary tract cancer and obstructive jaundice and other diseases can be significantly increased their vitality, the increase rate for the screening of hepatobiliary disease is a desirable indicator. In order to observe the clinical application value of this enzyme in various stages of schistosomiasis, we detected γ-GTP in 178 cases of schistosomiasis in various stages in 1980, and measured SGPT and AKP at the same time. The results reported below: