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目的了解性病门诊生殖器念珠菌病的易感因素、致病菌及对抗真菌药物的敏感性。方法收集疑似病例,通过真菌学确诊后进行流行病学调查,并进行菌种鉴定和体外药敏试验。结果168例疑似患者共分离培养出念珠菌46株(白念珠菌44株占95.6%、克柔念珠菌1株、光滑念珠菌1株);配偶/性伴患病、广谱抗菌素的应用等与本病相关;对抗真菌药的敏感性分别为酮康唑(KCZ)97.7%、伊曲康唑(ICZ)84.1%、特比萘芬(TBF)63.6%、两性霉素B(AMB)88.6%、咪康唑(MCZ)93.2%、氟康唑(FCZ)95.5%、5-氟胞嘧啶(5-FC)90.9%;ICZ和KCZ对FCZ耐药株的最低抑菌浓度(MIC)值偏高。结论配偶/性伴患病是最主要的易感因素;致病菌以白念珠菌为主,唑类药物存在交叉耐药倾向。
Objective To understand the susceptibility factors of genital candidiasis in STD clinics and the susceptibility of pathogens and antifungal agents. Methods Suspected cases were collected, epidemiological investigation confirmed by mycology, and strain identification and drug susceptibility testing in vitro. Results A total of 46 Candida albicans strains were isolated from 168 suspected cases (44 Candida albicans accounted for 95.6%, Candida krusei 1, Candida glabrata 1), the spouse / partner and the broad-spectrum antibiotics The sensitivity to antifungal agents was 97.7% for ketoconazole (KCZ), 84.1% for itraconazole (ICZ), 63.6% for terbinafine (TBF), 88.6% for amphotericin B (AMB) (MCZ), 95.5% fluconazole (FCZ) and 90.9% 5-fluorocytosine (5-FC). The minimum inhibitory concentration (MIC) of ICZ and KCZ against FCZ- High. Conclusion The prevalence of spouse / partner is the predominant predisposing factor; Candida albicans is the main cause of pathogenic bacteria, and the drug resistance of azoles is cross-resistant.