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作者以低剂量哌醋甲酯治疗童年多动综合征131例,年龄4～13岁,平均9.48岁,男116例,女15例,疗程1～6个月,治愈35例(26.72％),显著进步33例(25.19％),进步37例(28.24％),无效26例(19.84％),有效率80.15％,显效率51.90％。其中日量10毫克者显效率26.08％,日量20毫克者显效率53.53％,有显著差异;日量25～30毫克者全部是显效,差异非常显著。副作用方面植物神经性反应居首位(26.72％),是我国的第一次报告,其次为食欲减退(25.95％),但均轻微,多不影响继续治疗。
The authors treated 131 cases of childhood ADHD with low dose of methylphenidate, aged from 4 to 13 years (mean 9.48 years). There were 116 males and 15 females. The course of treatment ranged from 1 to 6 months, 35 cases (26.72%) were cured, Significant improvement in 33 cases (25.19%), progress in 37 cases (28.24%), 26 cases (19.84%) ineffective, effective rate was 80.15%, effective rate was 51.90%. Among them, the daily dose of 10 mg was 26.08%, the daily dose of 20 mg was 53.53%, with significant difference. The daily dosage of 25-30 mg was effective and the difference was significant. Side effects of autonomic nervous response ranked first (26.72%), is the first report of our country, followed by loss of appetite (25.95%), but were mild and did not affect the continued treatment.