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目的统计淄博市开展的中孕期三联血清学产前筛查和产前诊断的工作情况,比较两联和三联筛查方案在我市的筛查性能,验证三联筛查方案在本地人群中的可行性和有效性,评估其成本效益。方法回顾分析2011年3月至2011年11月4609例孕妇产前二联、三联筛查、羊水细胞染色体检查的情况并追踪其妊娠结局。结果三联筛查较二联筛查假阳性率降低,检出率提高,二联筛查漏诊1例,高风险人群接受产前诊断依从性差。结论三联筛查方案较二联筛查比较提高了筛查效率,uE3对非整倍体检出的敏感度较高、特异性强;产前筛查高风险孕妇及高龄孕妇在整个筛查人群中占比例高,接受羊膜腔穿刺的比例偏低,因此更好的开展产前咨询、加大产前诊断的宣传工作至关重要。
Objective To investigate the work of prenatal screening and prenatal diagnosis of triple serology in the second trimester of pregnancy in Zibo City and compare the screening performance of the two-and three-way screening programs in our city to verify the feasibility of triple-screening programs in the local population Sexual and effectiveness, to assess their cost-effectiveness. Methods A retrospective analysis of 4609 pregnant women from March 2011 to November 2011 in prenatal duplex, triple screening, amniotic fluid cell chromosome examination and follow-up of their pregnancy outcomes. Results The triple positive screening rate was lower than that of the second screening test, and the detection rate was increased. One case was missed by the second screening, and the poor prenatal diagnosis was poor in the high-risk population. Conclusions The triple screening program improves the screening efficiency compared with the second screening. The sensitivity of uE3 to aneuploidy is higher and the specificity is higher. The prenatal screening of high-risk pregnant women and elder pregnant women in the whole screening population Accounting for a high proportion of patients receiving amniocentesis a low proportion, so better prenatal counseling, increase prenatal diagnosis advocacy work is essential.