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金属化合物的遗传毒性研究比较少。大约30年前,Demerec和他的同事报道某些铁、锰和汞的化合物在细菌中可引起点突变。Nishi-oka指出,重组缺陷型试验阳性金属化合物中,重铬酸钾、钼酸铵和亚砷酸钠是诱变剂。细菌重组缺陷型试验也证实砷、铬和硒化合物具有诱变性。作者对127种金属化合物,用重组缺陷型试验和回变试验进行诱变性检测。重组缺陷型试验用枯草杆菌H17(Rec~+arg~-try~-)和M45(Rec~-,arg~-try~-)菌株。在加金属化合物后和37℃培养之前进行“冷培养”,即培养皿在4℃保存24小时,这样延长了金属化合物和非正在
The genetic toxicity of metal compounds is relatively small. About 30 years ago, Demerec and his colleagues reported that certain compounds of iron, manganese and mercury caused point mutations in bacteria. Nishi-oka pointed out that the recombinant defective test positive metal compounds, potassium dichromate, ammonium molybdate and sodium arsenite is a mutagen. Bacterial recombination deficiencies also demonstrated that arsenic, chromium and selenium compounds are mutagenic. The author of 127 kinds of metal compounds, recombinant defect test and back to the mutagenicity test. Bacillus subtilis H17 (Rec ~ + arg ~ -try ~ -) and M45 (Rec ~ -, arg ~ -try ~ -) strains were used for the recombinant defect test. The “cold culture” is carried out after addition of the metal compound and before incubation at 37 ° C., ie the dish is kept at 4 ° C. for 24 hours, thus prolonging the metal compound and non-positive