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迅速发展的产前诊断技术为及早治疗胎儿遗传缺陷性疾病提供了可能。胎儿独特的生物学优势使其成为干细胞移植最理想的受体。宫内干细胞移植对治疗许多遗传性疾病具有较大的潜力。虽然宫内干细胞移植在动物实验中取得了一定的成绩,但由于宫内干细胞移植存在植入障碍,尚不能达到临床治疗水平的植入率,故目前临床策略主要是通过产前干细胞移植诱导供体特异性免疫耐受,以便于产后同一供体细胞移植,从而提高嵌合体水平。应用干细胞移植已成功的治疗了一些血液系统、免疫系统及代谢性疾病。
The rapid development of prenatal diagnostic techniques for the early treatment of fetal genetic defects in the disease may provide. The unique biological advantage of the fetus makes it an ideal recipient for stem cell transplantation. Intrauterine stem cell transplantation for the treatment of many genetic diseases have great potential. Although intrauterine stem cell transplantation in animal experiments has made some achievements, but because of intrauterine implantation of intrauterine transplantation impaired, still can not reach the clinical treatment level of implantation rate, so the current clinical strategy is mainly induced by prenatal stem cell transplantation for Body-specific immune tolerance, in order to facilitate the same donor cell transplantation postpartum, thereby increasing the level of chimerism. Application Stem cell transplantation has been successful in the treatment of some of the blood system, immune system and metabolic diseases.