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阴道是恶性滋养细胞肿瘤常见的转移部位,仅次于肺,占第二位。阴道转移瘤一般随着5—氟脲嘧啶(5—Fμ)、更生霉素(K.S.m)全身化疗而治愈,然而有些病例却效果不佳,甚至完全无效。1981年我们遇到一例绒癌合并肺及阴道转移的病例,用5—Fμ及KSm全身化疗6个疗程后,肺转移灶消失,但阴道转移瘤却越来越发展,加用5—Fμ瘤体注射两个疗程也无效,后改用氨甲喋呤(MTX)、更生霉素、长春新碱(VCR)三联化疗三个疗程后,阴道转移瘤完全消失。此后我们用同法连续治疗6例,取得良好效果。现小结如下:
Vagina is a common metastatic site of malignant trophoblastic tumor, second only to the lung, accounting for the second place. Vaginal metastases generally cure with systemic chemotherapy with 5-fluorouracil (5-Fμ) and dactinomycin (K.S.m), but in some cases they are ineffective or even completely ineffective. In 1981, we encountered a case of choriocarcinoma associated with lung and vaginal metastasis, with 5-Fμ and KSm systemic chemotherapy six courses, the lung metastases disappear, but the vaginal metastases are more and more development, plus 5-F tumor Body injection of two courses also invalid, after the switch to methotrexate (MTX), dactinomycin, vincristine (VCR) triple chemotherapy three courses, the vaginal metastases completely disappeared. Since then we use the same method of continuous treatment of 6 cases, and achieved good results. Now summarized as follows: